Crenolanib Trifluoroacetic Acid Salt
酪氨酸激酶抑制剂
Crenolanib Trifluoroacetic Acid Salt
酪氨酸激酶抑制剂
Crenolanib Trifluoroacetic Acid Salt
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产品编号： CCR781800
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CAS号： 1797008-57-1
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相关CAS号：670220-88-9（自由胺）
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分子式：C28H30F3N5O4
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分子量：557.56
英文别名：
1-[2-[5-[(3-Methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine Trifluoroacetic Acid Salt; ARO 002 Trifluoroacetic Acid Salt; CP 868596 Trifluoroacetic Acid Salt; [1-[2-[5-(3-Methyloxetan-3-ylmethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-yl]amine Trifluoroacetic Acid Salt;
熔点：
217-220°C
可溶性：
DMSO, Methanol
性状：
白色至灰白色固体
SMILES：
O=[13C]1[13CH2]N([13CH3])[13C](N)=N1
储存条件：
冷藏
参考文献：
Michael, M. et al.: Br. J. Cancer, 103, 1554 (2010); Lewis, N.L. et al.: J. Clin. Oncol., 27, 5262 (2009);
Crenolanib (CP-868569) is a tyrosine kinase inhibitor that acts by specifically inhibiting the receptor tyrosine kinases PDGFRα and PDGFRβ. Crenolanib (CP-868569) inhibits the activity of PDGFRα D842V kinase and prevented the phosphorylation of wild type PDGFRα. Crenolanib (CP-868569) possesses potential antineoplastic activity. Crenolanib is believed to suppress PDGFR-related signal transduction pathways leading to the inhibition of tumor angiogenesis and tumor cell proliferation.
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