CP-100356 Monohydrochloride
MDR1(P-Gp)抑制剂
CP-100356 Hydrochloride
MDR1(P-Gp)抑制剂
CP-100356 Hydrochloride
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产品编号： CCR781250
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CAS号： 142715-48-8
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分子式：C31H37ClN4O6
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分子量：597.1
英文别名：
4-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxy-2-quinazolinamine Monohydrochloride
熔点：
210-212°C
可溶性：
Chloroform, Methanol
性状：
灰白色至浅褐色固体
SMILES：
O.Cl.Cl.COC1=CC=CC=C1CN[C@@H]1CCCN[C@@H]1C1C=CC=CC=1
储存条件：
冷藏
参考文献：
Ayrton, A., et al.: Xenobiotica, 31, 469 (2001), Mizuno, N., et al.: Pharmacol. Rev., 55, 425 (2003), Fojo, T., et al.: Clin. Breast Cancer, 7, 749 (2007), Polli, J., et al.: Drug Metab. Dispos., 36, 695 92008),
CP-100356 is a specific inhibitor of MDR1 (P-Gp), the protypical ABC transporter. CP-100356 also inhibits prazosin transport in human breast cancer resistance protein (BCRP)-transfected MDCKII cells, suggesting that it acts as a dual inhibitor. CP-100356 does not inhibit multidrug resistance-associated protein 2 (MPR2 IC50 >15 mM).
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