Clasto-lactacystin β-Lactone
断裂乳胞素；诱裂乳胞素；畸变乳胞素
Clasto-lactacystin (Omuralide)
断裂乳胞素；诱裂乳胞素；畸变乳胞素
Clasto-lactacystin (Omuralide)
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产品编号： CCR562500
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CAS号： 154226-60-5
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分子式：C10H15NO4
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分子量：213.23
英文别名：
(1R,4R,5S)-1-[(1S)-1-Hydroxy-2-methylpropyl]-4-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione; Clasto-lactacystin β-Lactone; Omuralide
熔点：
186-187°C
可溶性：
DMF, Ethanol, Hot Ethyl Acetate, Methanol, Pyridine
性状：
White Solid
SMILES：
CO/N=C1\[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@H](O)[C@](C)(OC)C2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]\1C
储存条件：
-20°C
参考文献：
Craiu, A., et al.: J. Biol. Chem., 272, 13437 (1997), Dick, G.L.R., et al.: J. Biol. Chem., 272, 182 (1997), Fenteany, G. and Schreiber, S.: J. Biol. Chem., 273, 8545 (1998), Corey, E.J., et al.: J.A.C.S., 120, 2330 (1998)
A cell permeable, irreversible proteasome inhibitor. It is 20-fold more potent than Lactacystin. Lactacytstin spontaneously converts to clasto-lactacystin in biological systems. Clasto-lactacystin is the only cell permeable form of lactacystin. Induces neurite growth and inhibits cell cycle progression similar to lactacytin.
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