胞磷胆碱钠
胞磷胆碱钠
Citicoline Sodium Salt
胞磷胆碱钠
Citicoline Sodium Salt
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产品编号： CCR508050
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CAS号： 33818-15-4
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相关CAS号：Free Acid: 987-78-0
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分子式：C₁₄H₂₅N₄NaO₁₁P₂
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分子量：510.31
英文别名：
Cytidine 5’-(Trihydrogen Diphosphate) P’-[2-(Trimethylammonio)ethyl] Ester Inner Salt Sodium Salt; Acticolin; Brassel; Cebroton; Cidifos; Citicoline Sodium; Flussorex; Gerolin; IP 302 Sodium; Logan; Neurotron; Sinkron;
熔点：
>240°C (dec.)
可溶性：
Water
性状：
White Solid
SMILES：
N#CC1C=CC2C(C3C=CC(F)=CC=3)(CCC[N+]([O-])(C)C)OCC=2C=1
储存条件：
-20°C
参考文献：
Castagna A, et al. Clin Drug Investig. 2016 Sep 1 PMID: 27587069 Abdolmaleki A, et al. 2016. Eur J Pharmacol. Oct 15;789:275-9 PMID: 27475676 Abdel-Zaher AO et al. Toxicol Ind Health. 2016 May 13 PMID: 27178312
Naturally occurring nucleotide; intermediate in the major pathway of lecitin biosynthesis. Neuroprotective. It is used in the treatment of ischemic stroke and head trauma. Neuroprotective product. Citicholine exhibits protective effects in cerebral ischemia, traumatic brain injury, and memory disorders. Recently showed efficacy against dementia when given with AchEIs (Acetylcholinesterase inhibitor) (1). Depicts Neuroprotective, acnticonvulsant activity and sedative effect at a dose of 150mg/kg in rats. (2). Showed protection against aluminum induced cognitive impairment in rats reducing elevated glutamate level, oxidative stress and NO overproduction in the hippocampus.
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