Ipatasertib
GDC-0068; RG 7440
(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone
GDC-0068; RG 7440
(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone
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产品编号： CCR377870
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CAS号： 1001264-89-6
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分子式：C24H32ClN5O2
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分子量：458
英文别名：
GDC-0068; Ipatasertib; RG 7440
熔点：
>106°C (dec.)
可溶性：
Acetonitriele (Slightly), DMSO (Slightly), Methanol (Slightly)
性状：
Peach Solid
SMILES：
CC(NCC(C(N1CCN(C2=NC=NC3C(CC(C)C2=3)O)CC1)=O)C1=CC=C(Cl)C=C1)C
储存条件：
冷藏
参考文献：
Jie, L., et al.: Clin. Cancer. Res., 10, 1078 (2013);
(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone is a highly selective AKT inhibitor targeting Akt1, Akt2 and Akt3. Studies have shown its use in combination with vemurafenib (V118500), have demonstrated therapeutic value in the treatment of hyperproliferative disorders such as cancer.
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