4-氯犬尿氨酸-13C2,15N
4-氯犬尿氨酸-13C2,15N；4-氯犬尿素-13C2,15N；α,2-二氨基-4-氯-γ-酮代苯丁酸-13C2,15N
4-Chloro Kynurenine-13C2,15N
4-氯犬尿氨酸-13C2,15N；4-氯犬尿素-13C2,15N；α,2-二氨基-4-氯-γ-酮代苯丁酸-13C2,15N
4-Chloro Kynurenine-13C2,15N
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产品编号： CCR366942
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CAS号： 1391051-72-1
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相关CAS号：75802-84-5（未标记）
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分子式：C813C2H11ClN15NO3
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分子量：245.64
英文别名：
α,2-Diamino-4-chloro-γ-oxobenzenebutanoic Acid-13C2,15N; (+/-)-α,2-Diamino-4-chloro-γ-oxobenzenebutanoic Acid-13C2,15N; 4-Cl-KYN-13C2,15N; (+/-)-AV-101-13C2,15N;
熔点：
>195°C (dec.)
可溶性：
Aqueous Acid (Slightly)
性状：
Pale Yellow Solid
储存条件：
-20°C
参考文献：
Leeson, P., et al.: J. Med. Chem., 37, 4053 (1994), Hilmas, C., et al.: J. Neurosci., 2001, 21, 7463 (2001), Palmer, G., et al.: Curr. Drug Targets, 2, 241 (2001), Wu, H., et al.: Exp. Neurol., 177, 222 (2002),
7-Cl-kynurenic acid (7-Cl-KYNA) is a potent, selective antagonist of the NMDA/glycine receptor but penetrates poorly through the blood-brain barrier. Its prodrug, L-4-Cl-kynurenine (4-Cl-KYN), readily enters the brain from the circulation and provides antiexcitotoxic neuroprotection after systemic application.
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