CHIR-99021 Hydrochloride
糖原合酶激酶-3抑制剂；GSK-3抑制剂
CHIR-99021 Hydrochloride
糖原合酶激酶-3抑制剂；GSK-3抑制剂
CHIR-99021 Hydrochloride
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产品编号： CCR292150
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CAS号： 1797989-42-4
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相关CAS号：252917-06-9(未标记)
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分子式：C₂₂H₁₉Cl₃N₈
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分子量：501.8
英文别名：
6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile; CHIR 911; CT 99021;
熔点：
>238°C (dec.)
可溶性：
DMSO (Slightly), Methanol (Slightly)
性状：
Off-White to Pale Beige Solid
SMILES：
N#CC1=CC=C(NCCNC2=NC=C(C3=NC=C(C)N3)C(C4=CC=C(Cl)C=C4Cl)=N2)N=C1.[H]Cl
储存条件：
冷藏
参考文献：
Ring, et al.: Diabetes, 52, 588 (2003); Tighe, et al.: Cell Biol., 8, 34 (2007); Pan, et al.: Neuropsychopharmacology, 36, 1397 (2011);
CHIR-99021 is a potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3). CHIR-99021 activates glycogen synthesis in CHO-IR cells and in isolated type 1 diabetic rat skeletal muscle. CHIR-99021 has also been shown to induce the reprogramming of murine and human somatic cells into stem cells.
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