雷公藤红素
雷公藤红素；南蛇藤醇
Celastrol
雷公藤红素；南蛇藤醇
Celastrol
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产品编号： CCR249500
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CAS号： 34157-83-0
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分子式：C29H38O4
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分子量：450.61
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EINECES：636-472-5
英文别名：
3-Hydroxy-2-oxo-24-nor-D:A-friedooleana-1(10),3,5,7-tetraen-29-oic Acid; Tripterin; Tripterine (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic Acid;
熔点：
187-189°C
可溶性：
DMSO, Chloroform, Methanol
性状：
Orange Red Solid
SMILES：
OC([C@]1(C)CC[C@]2(C)CC[C@]3(C)C4=CC=C5C(C)=C(C(C=C5[C@]4(C)CC[C@@]3(C)[C@]2([H])C1)=O)O)=O
储存条件：
-20°C
参考文献：
Senger, D., et al.: Science, 219, 983 (1983), Folkman, J., et al.: Nature, 1, 27 (1995), He, W., et al.: Bioorg. Med. Chem. Lett., 8, 3659 (1998), Grosios, K., et al.: Inflamm. Res., 53, 133 (2004), Yang, H., et al.: Cancer Res., 66, 4758 (2006); AAPS New
An antioxidant natural product which inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. Used for clinical treatment for rheumatoid arthritis, was demonstrated to have antiangiogenic activity, and be inhibitory against mice tumor growth by a few recent studies. Celastrol also has been shown to have the power to kill tumor cells and can work as an anticarcinogen. Celastrol is also a leptin sensitizer with the potential to reduce weight in obesity (see W499200).
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