CDDO-Im
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CDDO Imidazolide
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CDDO Imidazolide
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产品编号： CCR228090
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CAS号： 443104-02-7
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分子式：C34H43N3O3
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分子量：541.72
英文别名：
1-(2-Cyano-3,12,28-trioxooleana-1,9(11)-dien-28-yl)-1H-imidazole; 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid imidazolide; CDDO-Im; RTA 403; TP 235;
熔点：
>164°C (dec.)
可溶性：
Chloroform (Slightly), Methanol (Very Slightly)
性状：
Yellow to Tan Solid
SMILES：
N#CC1C(=O)C(C)(C)[C@H]2[C@](C3=CC(=O)[C@@H]4[C@@H]5CC(C)(C)CC[C@]5(C(N5C=CN=C5)=O)CC[C@@]4(C)[C@]3(C)CC2)(C)C=1
储存条件：
-20°C
参考文献：
Hughes, D.T. et al.: Cancer Invest., 26, 118 (2008); Place, A.E. et al.: Clin. Cancer Res., 9, 2798 (2003); Samudio, I. et al.: J. Biol. Chem., 280, 36273 (2005);
CDDO Imidozolide (CDDO-Im) is a synthetic triterpenoid CDDO-Im inhibits fatty acid synthase expression and has antiproliferative and proapoptotic effects in human liposarcoma cells. Studies show that CDDO-Im is highly active in suppressing cellular proliferation of human leukemia and breast cancer cell lines as well as being an effective therapeutic agent in the treatment of other types of cancers.
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