CCT036477
Wnt信号通路抑制剂
CCT036477
Wnt信号通路抑制剂
CCT036477
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产品编号： CCR227900
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CAS号： 305372-78-5
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分子式：C21H18ClN3
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分子量：347.84
英文别名：
α-(4-Chlorophenyl)-2-methyl-N-2-pyridinyl-1H-indole-3-methanamine;
熔点：
>167°C (dec.)
可溶性：
DMSO (Slightly), Ethyl Acetate (Slightly)
性状：
Off-White to Pale Beige Solid
SMILES：
ClC1C=CC(C(C2=C(C)NC3=CC=CC=C23)NC2=CC=CC=N2)=CC=1
储存条件：
冷藏
参考文献：
Ewan, K. et al.: Cancer Res., 14, 5963 (2010);
CCT036477 is an inhibitor of Wnt signaling. Studies show that CCT036477 does not alter β-catenin levels but blocks transcription at the β-catenin level. CCT036477 inhibited growth in several cancer cell lines and showed clear activity in vivo, blocking development of Zebrafish and Xenopus embryos and expression of Wnt target genes.
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