Canagliflozin
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Canagliflozin
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Canagliflozin
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产品编号： CCR175190
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CAS号： 842133-18-0
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分子式：C24H25FO5S
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分子量：444.52
英文别名：
(1S)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol;
熔点：
68-72°C
可溶性：
DMSO (Slightly), Methanol (Slightly)
性状：
White to Pale Yellow Solid
SMILES：
FC1=CC=C(C2=CC=C(CC3C(C)=CC=C([C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C=3)S2)C=C1
储存条件：
-20°C
参考文献：
Chao, E. et al.: Drug Fut., 36, 351 (2011); Sha, S. et al.: Diab. Obes. Metab., 13, 669 (2011); Kipnes, M.S.: Clin. Invest., 1, 145 (2011);
Canagliflozin is a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity.
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