(S)-(-)-四氢小檗碱
(S)-(-)-四氢小檗碱；L-四氢小檗碱；α-四氢小檗碱
(S)-(-)-Canadine
(S)-(-)-四氢小檗碱；L-四氢小檗碱；α-四氢小檗碱
(S)-(-)-Canadine
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产品编号： CCR175180
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CAS号： 5096-57-1
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分子式：C20H21NO4
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分子量：339.39
英文别名：
(S)-5,8,13,13a-tetrahydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine; Canadine; (-)-Canadine; (-)-Tetrahydroberberine; (-)-α-Canadine; (S)-(-)-7,8,13,13a-Tetrahydroberberine; (S)-(-)-Tetrahydroberberine; (S)-Canadine; (S)-Tetrahydroberberine; 9,10-Dimethoxy-2,3-(methylenedioxy)-13aα-berbine; l-Canadine; α-Canadine
熔点：
132-134°C
可溶性：
Chloroform, Ethyl Acetate (Slightly), Methanol (Very Slightly, Heated)
性状：
Pale Yellow to Light Yellow Solid
SMILES：
COC1=C(OC)C2=C(C[C@@H]3N(C2)CCC2C3=CC3=C(C=2)OCO3)C=C1
储存条件：
冷藏
参考文献：
Sun, H. et al.: Bioorg. Med. Chem., 21, 856 (2013); Deeb, O., et al.: Chem. Biol. Drug Des., 76, 255 (2010); Sun., et al.: Br. J. Pharmcol., 158, 1302 (2009); Duchowicz, P., et al.: Bioorg. Med. Chem., 14, 5876 (2006); Yamahara, J. et al.: Chem. Pharm. Bu
(S)-(-)-Canadine is a protoberberine alkaloid which potently block functional KATP channels natively expressed on midbrain dopamine neurons. Canadine is used for treatment of degenerative diseases or conditions associated with KATP channel signaling. (S)-(-)-Canadine has a strong central nervous system-depressing activity and is used in the preparation of tetrahydroprotoberberine derivatives as new antipsychotic agents.
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