卡博替尼 L-苹果酸盐
卡博替尼 L-苹果酸盐
Cabozantinib L-Malate Salt
卡博替尼 L-苹果酸盐
Cabozantinib L-Malate Salt
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产品编号： CCR051500
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CAS号： 1140909-48-3
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相关CAS号：849217-68-1-free base
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分子式：C32H30FN3O10
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分子量：635.59
英文别名：
N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N’-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (2S)-2-Hydroxybutanedioic Acid; Cabozantinib S-Malate; XL 184;
熔点：
166-169°C
可溶性：
DMSO (Slightly), Methanol (Slightly, Heated)
性状：
White to Off-White Solid
SMILES：
OC(CC(O)C(O)=O)=O.COC1C(OC)=CC2C(=NC=CC=2OC2=CC=C(NC(C3(C(NC4=CC=C(F)C=C4)=O)CC3)=O)C=C2)C=1
储存条件：
冷藏
参考文献：
Camp, R., et al.: Cancer, 86, 2259 (1999), Morello, S., et al.: J. Cell Physiol., 189, 285 (2001), Zhang, Y., et al.: Oncogene, 21, 217 (2002), Wells, S., et al.: J. Clin. Oncol., 28, 767 (2010),
Cabozantinib is a small molecule C-Met modulator. Cabozantinib acts as a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature and extensive tumor cell apoptosis.
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