卡巴他赛
卡巴他赛
Cabazitaxel
卡巴他赛
Cabazitaxel
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产品编号： CCR046500
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CAS号： 183133-96-2
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分子式：C45H57NO14
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分子量：835.93
英文别名：
(αR,βS)-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxybenzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester; TXD 258; XRP 6258; β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxybenzenepropanoic Acid [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-12b-(Acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester;
熔点：
>151°C (dec.)
可溶性：
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
性状：
White Solid
SMILES：
CC(OC(N[C@H]([C@H](C(O[C@H]1C[C@]2([C@H]([C@H]3[C@@](C([C@H](OC)C(C2(C)C)=C1C)=O)(C)[C@@H](OC)C[C@H]1OC[C@@]31OC(=O)C)OC(C1C=CC=CC=1)=O)O)=O)O)C1C=CC=CC=1)=O)(C)C
储存条件：
-20˚C
参考文献：
Agarwal, N. et al.: Fut. Oncol., 7, 15 (2011); Mita, A. et al.: Clin. Cancer Res., 15, 723 (2009); Figg, W.D. et al.: Cancer Biol. Ther., 10, 1233 (2010);
A novel semi-synthetic taxane with antitumor activity used for the treatment of castration-resistant prostate cancer. A microtubule inhibitor.
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