AZD8055
mTOR激酶抑制剂
AZD8055
mTOR激酶抑制剂
AZD8055
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产品编号： CAR808130
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CAS号： 1009298-09-2
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分子式：C25H31N5O4
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分子量：465.54
英文别名：
5-[2,4-Bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol; [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]- 2-methoxyphenyl]methanol; AZD 8055; [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]py
熔点：
204-207°C
可溶性：
DMSO (Slightly), Methanol (Slightly)
性状：
Pale Yellow to Light Yellow Solid
SMILES：
OCCC(/N=C(\O)/C1(CCN(C2=C3C=CNC3=NC=N2)CC1)N)C1=CC=C(Cl)C=C1
储存条件：
冷藏
A potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. It inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1 as well as phosphorylation of the mTORC2 substrate AKT and downstream protein
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