6-氨基-4-(4-苯氧基苯乙氨基)喹唑啉
NFkB抑制剂
6-Amino-4-(4-phenoxyphenylethylamino)quinazoline
NFkB抑制剂
6-Amino-4-(4-phenoxyphenylethylamino)quinazoline
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产品编号： CAR621350
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CAS号： 545380-34-5
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分子式：C22H20N4O
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分子量：356.42
英文别名：
N4-[2-(4-Phenoxyphenyl)ethyl]-4,6-quinazolinediamine; QNZ;
熔点：
>170°C (dec.)
可溶性：
DMSO, Methanol (Sparingly)
性状：
Off-White to Brownish-Yellow Solid
SMILES：
NC1C=CC(NS(C)(=O)=O)=C(OC2C=CC=CC=2)C=1
储存条件：
冷藏
QNZ is a novel inhibitor of NFkB which displays potent inhibitory effects on both NFKB transcriptional activation (IC50=11nM) and TNF-α production (IC50=7nM). It dose-dependently inhibited carragenin-induced edema formation in the rat paw model (1mg/Kg).
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