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阿洛司他丁
阿洛司他丁;阿洛司他汀
E-64d;Loxistatin;Aloxistatin
  • 产品编号: E100500

  • CAS号: 88321-09-9

  • 分子式:C17H30N2O5

  • 分子量:342.43

英文别名:
(2S,3S)-3-[[[(1S)-3-Methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-2-oxiranecarboxylic Acid Ethyl Ester; Aloxistatin; E 64c ethyl ester; E 64d; EP 453; EST; EST (pharmaceutical); Loxistatin; NSC 694281
SMILES:
CC(C)CCNC(=O)C(CC(C)C)NC(=O)[C@@H]1[C@@H](C(=O)OCC)O1
参考文献:
Wilcox, D. et al.: Biochem. J., 285, 495 (1992); McGowan, E.B. et al.: Biochem. Biophys. Res. Comm., 158, 432 (1989); Tsubokawa, T. et al.: J. Neurosci. Res., 84, 832 (2006);
E-64d is an inhibitor of cathepsins B and L as well as a potential inhibitor of calpain. E-64d has been shown to inhibit lysosomal proteases. E-64d has been used in combination with Prepstatin A to interfere with autolysosomal digestion. E-64d displays neurovascular and neuronal protective effects after focal cerebral ischemia in rats.
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